Diet and Nutrition – Vitamin B6
- by Andrew Evans
Vitamin B6 occurs in 3 forms–pyridoxine, pyridoxal, and pyridoxamine. B6 is absorbed in the large intestine. The muscle stores approximately 75 80 % of the vitamin although the live stores approximately 5 10 %.
B6 is required for transaminations, ammonia release,, side chain cleavage reactions, dehydratases and decarboxylations. Its aldehyde group functions as a Schiff base to react with the amino groups of amino acids. It essentially acts to shuttle nitrogen between compounds.
Functions- The three sorts of B6 can all be switched into on the coenzyme PLP that helps in transamination and protein metabolism. PLP is important for glycogen degradation; furthermore, it will help with the formation of the neurotransmitter, serotonin, the nonprotein part of hemoglobin (heme), nucleic acids, and lecithin. Vitamin B6 is important for the metabolic rate of tryptophan to niacin.
· Transaminations These reactions are required to recycle and reuse nitrogen in the entire body. They’re the first stage in amino acid catabolism and also the last stage in the synthesis of nonessential amino acids. Example: a-ketoglutarate + asparate glutamate + oxaloacetate
· Serine/ Threonine Deamination (Dehydratases) This reaction provides the production of the a keto acids of serine and threonine through oxidative removal of N as ammonia Example: Serine a-keto-serine + NH4+
· Decarboxylation These reactions typically occur on the neuroactive amines of seratonin, tyramine, histamine, and GABA. They also are crucial in porphyrin synthesis, intermediates within the synthesis of sphingomyelin, taurine and lecithin, as well as for the breakdown and desulfuration of cysteine.
· Glycogen Phosphorylase fifty % of all B6 within the body is bound to glycogen phosphorylase but the importance is unknown. The reaction is important for recycling of folate and is as follows:
Serine glycine + 5,10-methylene-THF
Deficiency Deficiencies of vitamin B6 are relatively uncommon. Individuals with a diet deficient in vitamin B6 will first show signs of weakness, irritability, insomnia, nervousness, and moist skin lesions. More advanced symptoms include things like growth failure, impaired motor function, hypochromic microcytic anemia, sleek tongue, along with convulsions.
The impaired motor function and other psychological issues could be linked to a reduction in amino acid-based neurotransmitters (serotonin, tyramine, GABA, epinephrine). You see an increase in urea excretion due to a decline synthesis of nonessential amino acids. The nitrogen from these amino acids is not recycled by transamination and instead is excreted and lost. You see an increase in urinary excretion particularly inside the following amino acids: metabolites of glycine, methionine, and tryptophan. The hypochromic microcytic anemia is mainly because that there is a decreased synthesis of the B6 dependent porphyrin ring of hemoglobin.
Individuals who are at most risk are the elderly with poor vitamin intake, hemodialysis patients, alcoholics, and those that are on drug therapy. General, individuals with a high metabolic stress.
meal prep delivery services in vitamin B6 include:
o whole grains o legumes o nuts o navy beans o walnuts o meat (sirloin plus chicken) o fish (salmon plus shellfish) o bananas and apples o broccoli and spinach
Therapeutics Vitamin B6 could provide therapeutic benefits because of the next syndromes: carpal tunnel syndrome, glucose intolerance, sideroblastic anemia, neurologic disorders, hyperoxaluria, convulsive seizures, monosodium glutarate (MSG) intolerance, premenstral syndrome (Immune function and pms). Moreover, vitamin B6 may possibly help decrease homocysteine levels and therefore the risk of getting cardiovascular disease.
Vitamin B6 occurs in 3 forms–pyridoxine, pyridoxal, and pyridoxamine. B6 is absorbed in the large intestine. The muscle stores approximately 75 80 % of the vitamin although the live stores approximately 5 10 %. B6 is required for transaminations, ammonia release,, side chain cleavage reactions, dehydratases and decarboxylations. Its aldehyde group functions as a Schiff…